Novel tocopheryl compounds. Part 15: One-pot formation of furotocopheryl derivatives

Reaction of tocopheryl bromide or chromanyl bromide with triphenyl phosphine produced phosphomium salt intermediates (), which further reacted with acyl chlorides to novel furotocopherol compounds in good yields. The cyclization proceeded according to a two step esterification–Wittig mechanism. Similarly, furotocopheryl dimer was prepared starting from oxalyl chloride. The coupling of tocopheryl phosphonium salt onto modified polystyrene provided a new, vitamin E-loaded resin.