Title of article
Free radical reactions for heterocycle synthesis. Part 7: 2-Bromobenzoic acids as building blocks in the construction of spirobenzolactones and spirobenzolactams
Author/Authors
Wei Zhang، نويسنده , , Georgia Pugh، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
11
From page
4237
To page
4247
Abstract
A straightforward 2-step parallel synthesis for structurally diversified spiro compounds is developed. 2-Bromobenzoic acids are used as common building blocks to couple with a series of conjugated enoles or enamines. Sequential intramolecular free radical Michael additions lead to formation of spirobenzolactones, spirobenzolactams, spirobenzolactone-lactams, spiorbenzolactone-thiolactones, spiordilactones, and bridged-spirolactones.
Keywords
2-bromobenzoic acid , Free radical , tris(trimethylsilyl)silane , Michael addition , spirolactone
Journal title
Tetrahedron
Serial Year
2003
Journal title
Tetrahedron
Record number
1087845
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