Title of article
Practical synthesis of 1-deoxy-d-xylulose and 1-deoxy-d-xylulose 5-phosphate allowing deuterium labelling
Author/Authors
Odile Meyer، نويسنده , , Jean-François Hoeffler، نويسنده , , Catherine Grosdemange-Billiard، نويسنده , , Michel Rohmer، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
10
From page
12153
To page
12162
Abstract
An optimised gram scale synthesis allows the production of 1-deoxy-d-xylulose and 1-deoxy-d-xylulose 5-phosphate with possible deuterium labelling at C-5. Such substrates are required for investigations on the mevalonate-independent 2-C-methyl-d-erythritol 4-phosphate pathway for isoprenoid biosynthesis in bacteria and chloroplasts of phototrophic eukaryotes and for the biosynthesis of vitamins B1 (thiamine diphosphate) and B6 (pyridoxol phosphate) in bacteria.
Keywords
Biosynthesis , 1-Deoxy-d-xylulose , 1-Deoxy-d-xylulose 5-phosphate , Deuterium labelling , Pyridoxol phosphate , 2-C-methyl-d-erythritol 4-phosphate , isoprenoids , 1-Deoxy-d-threo-2-pentulose , Thiamine diphosphate
Journal title
Tetrahedron
Serial Year
2004
Journal title
Tetrahedron
Record number
1088210
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