Title of article
Synthesis and biological evaluation of (±)-cryptotanshinone and its simplified analogues as potent CDC25 inhibitors
Author/Authors
Wei Gang Huang، نويسنده , , Ying Yan Jiang، نويسنده , , Qian Li، نويسنده , , Jia Li، نويسنده , , Jing Ya Li، نويسنده , , Wei Lu، نويسنده , , Jun Chao Cai، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
8
From page
1863
To page
1870
Abstract
(±)-Cryptotanshinone and its simplified analogues were synthesized via SmI2 promoted radical cyclization to construct the furan ring. Analogues and were identified as effective inhibitors of dual specificity protein phosphatase CDC25B which is a key enzyme for cell cycle progression, and they also inhibited growth in A-549 human lung cancer cell line.
Keywords
Antitumor , CDC25 Inhibitor , Cryptotanshinone , Analogues
Journal title
Tetrahedron
Serial Year
2005
Journal title
Tetrahedron
Record number
1088417
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