Title of article
Tandem alkylation–cyclization process via an O,C-dianion
Author/Authors
April R. Banaag، نويسنده , , Gideon O. Berger، نويسنده , , Francis Dhoro، نويسنده , , Derrick B. delos Santos، نويسنده , , Darryl D. Dixon، نويسنده , , James P. Mitchell، نويسنده , , Bradley K. Tokeshi، نويسنده , , Marcus A. Tius، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
10
From page
3419
To page
3428
Abstract
A general protocol for preparing densely functionalized cyclopentenones through a tandem nucleophilic addition–deprotonation–alkylation–cyclization process is described. Addition of lithioallene to enamides generates tetrahedral intermediate . Deprotonation of the γ carbon atom of the allene function in situ, followed by trapping by a suitable electrophile and cyclization during workup leads to C6 substituted cyclopentenones .
Keywords
Cyclization , Nazarov , Allene
Journal title
Tetrahedron
Serial Year
2005
Journal title
Tetrahedron
Record number
1088564
Link To Document