Title of article
An efficient synthesis of 5-aminolaevulinic acid (ALA)-containing peptides for use in photodynamic therapy
Author/Authors
Louis M.-A. Rogers، نويسنده , , Philip G. McGivern، نويسنده , , Anthony R. Butler، نويسنده , , Alexander J. MacRobert، نويسنده , , Ian M. Eggleston، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
8
From page
6951
To page
6958
Abstract
An efficient and cost-effective procedure has been devised for the preparation of urethane-protected 5-aminolaevulinic acid (5-ALA) dipeptide ester derivatives which avoids problems associated with the instability of 5-ALA under basic conditions. The procedure is also applicable to the direct synthesis of N-(α)-acetyl amino acid-ALA dipeptides in high enantiomeric purity as potential novel prodrugs for photodynamic therapy (PDT).
Keywords
Aminolaevulinic acid , Photodynamic therapy , Peptide , Prodrug
Journal title
Tetrahedron
Serial Year
2005
Journal title
Tetrahedron
Record number
1088912
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