Title of article
An unusual stereochemical outcome of radical cyclization: synthesis of (+)-biotin
Author/Authors
Subhash P. Chavan، نويسنده , , Amar G. Chittiboyina، نويسنده , , Guduru Ramakrishna، نويسنده , , Rajkumar B. Tejwani، نويسنده , , T. Ravindranathan، نويسنده , , Subhash K. Kamat، نويسنده , , Beena Rai، نويسنده , , Latha Sivadasan، نويسنده , , Kamalam Balakrishnan، نويسنده , , S. Ramalingam، نويسنده , , V.H. Deshpande، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
8
From page
9273
To page
9280
Abstract
An enantioselective synthesis of (+)-biotin starting from naturally available cysteine is described. The key steps are the unusual stereochemical outcome of radical cyclization of compound to prepare 5,5-fused system , and the introduction of C4-sidechain at C6 in via a Grignard reaction.
Keywords
Biotin , Radical cyclization , Exocyclization
Journal title
Tetrahedron
Serial Year
2005
Journal title
Tetrahedron
Record number
1089153
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