Title of article
Stereoselective Mannich-type reaction of chlorotitanium α-phenylseleno esters enolates with aromatic aldimines
Author/Authors
Claudio C. Silveira، نويسنده , , Adriano S. Vieira، نويسنده , , Antônio L. Braga، نويسنده , , Dennis Russowsky، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
7
From page
9312
To page
9318
Abstract
The stereoselective Mannich-type reaction of α-phenylseleno chlorotitanium enolates with aromatic aldimines is described. The corresponding α-phenylseleno-β-amino esters were obtained in good yields and with moderate to good diastereoselectivity. A rationale for the predominant syn selectivity based on a chelated cyclic transition state is suggested. The obtained compounds are useful synthetic tools and direct precursors of new α-phenylseleno-β-lactams.
Keywords
Mannich reaction , Phenylseleno esters , Stereoselective , ?-Seleno-?-amino esters
Journal title
Tetrahedron
Serial Year
2005
Journal title
Tetrahedron
Record number
1089158
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