Title of article
Facile one-pot synthesis of BINOL- and H8-BINOL-based aryl phosphites and their use in palladium catalysed asymmetric allylation
Author/Authors
Konstantin N. Gavrilov، نويسنده , , Sergey E. Lyubimov، نويسنده , , Pavel V. Petrovskii، نويسنده , , Sergey V. Zheglov، نويسنده , , AntonS. Safronov، نويسنده , , Roman S. Skazov، نويسنده , , Vadim A. Davankov، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
7
From page
10514
To page
10520
Abstract
Novel P-monodentate aryl phosphite ligands have been synthesised in one step from (R)-BINOL, (R)-H8-BINOL and (R)-H8-3,3′-dibromo-BINOL. With the new aryl phosphites, up to 86% ee was observed in the asymmetric Pd-catalysed amination of 1,3-diphenyl-2-propenyl acetate with sodium diformylamide. In the enantioselective alkylation of 1,3-diphenyl-2-propenyl acetate with dimethyl malonate, up to 97% enantioselectivity was achieved.
Keywords
Enantioselective alkylation , P-monodentate phosphite ligands , Asymmetric Pd-catalysed amination
Journal title
Tetrahedron
Serial Year
2005
Journal title
Tetrahedron
Record number
1089279
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