Title of article
Preparation of novel 3H-trifluoromethyldiazirine-based photoactivatable potassium channel antagonists
Author/Authors
John M. Sanderson، نويسنده , , John B.C. Findlay and Helen R. Saibil، نويسنده , , Colin W.G. Fishwick، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
9
From page
11244
To page
11252
Abstract
The preparation of a series of photoactivatable precursors for use in photoaffinity labelling of potassium channels is described. 3H-Diazirine functionalities were incorporated into the previously described potassium channel antagonists . The ability to perform enantioselective reductions and Wittig reactions in the presence of 3H-diazirines was central to this work.
Keywords
Diazirine , photoreactive , Stereoselective , Photolabile , Antagonist
Journal title
Tetrahedron
Serial Year
2005
Journal title
Tetrahedron
Record number
1089350
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