Title of article
Facile and purification free synthesis of peptides utilizing ROMPgel- and ROMPsphere-supported coupling reagents
Author/Authors
Anthony G.M. Barrett، نويسنده , , Brigitte Bibal، نويسنده , , Brian T. Hopkins، نويسنده , , Johannes K?bberling، نويسنده , , Andrew C. Love، نويسنده , , Livio Tedeschi، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
9
From page
12033
To page
12041
Abstract
5-Norbornene-2-carboxaldehyde and norbornadiene were respectively converted into norbornene derivatives functionalized with fluoroformamidinium hexafluorophosphate and 2-bromo-N-methylpyridinium tetrafluoroborate residues. Both these norbornene monomers were ring opening metathesis polymerized or graft copolymerized onto polystyrene cores to produce ROMPgel and ROMPsphere peptide-coupling reagents. These were used to prepare hindered amides, dipeptides and tripeptides with minimal purification in parallel arrays.
Keywords
Acylations , Combinatorial chemistry , Peptides , parallel synthesis , supported reagents
Journal title
Tetrahedron
Serial Year
2005
Journal title
Tetrahedron
Record number
1089420
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