Title of article
Asymmetric addition of trimethylsilyl cyanide to ketones catalyzed by Al(salen)/triphenylphosphine oxide
Author/Authors
Sung-Soo Kim، نويسنده , , Ju Myung Kwak، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2006
Pages
5
From page
49
To page
53
Abstract
Trimethylsilyl cyanide asymmetrically adds to various ketones by catalysis of /triphenylphosphine oxide. This is a double activation where acts as Lewis acid and Ph3PO Lewis base. Various ketones were subjected to the enantioselective addition so as to give up to 92% ee and >90% yield.
Keywords
Trimethylsilyl cyanide , asymmetric addition , Al(salen) , Ketone , cyanohydrin
Journal title
Tetrahedron
Serial Year
2006
Journal title
Tetrahedron
Record number
1089466
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