Asymmetric synthesis of a diastereomer of the structure proposed for amphidinolide A and the determination of its absolute configuration

An asymmetric synthesis of a diastereomer () of the structure () proposed for amphidinolide A, a cytotoxic macrolide from the cultured dinoflagellate Amphidinium sp., has been accomplished. The absolute configuration of amphidinolide A was established as from comparison of NMR data, HPLC analysis, and [α]D values of amphidinolide A, and comparison with the synthetic diastereomers and , the latter of which was synthesized previously by Trostʹs group.