Title of article
l-Proline amide-catalyzed direct asymmetric aldol reaction of aldehydes with chloroacetone
Author/Authors
Long He، نويسنده , , Zhuo Tang، نويسنده , , Lin-Feng Cun، نويسنده , , Aiqiao Mi، نويسنده , , Yaozhong Jiang، نويسنده , , Liu-Zhu Gong، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2006
Pages
6
From page
346
To page
351
Abstract
l-Proline amides were evaluated for catalyzing the direct aldol reaction of 4-nitrobenzaldehyde with chloroacetone. The presence of 30 mol% (S)-pyrrolidine-2-carboxylic acid (2,4,6-trimethyl-phenyl)-amide catalyzed the direct aldol reactions of a range of aldehydes with chloroacetone to give anti-α-chloro-β-hydroxyketones with high regio-, diastereo- and enantioselectivity.
Keywords
Chloroacetone , Organocatalyst , direct aldol reaction , l-proline amides , Asymmetric catalysis
Journal title
Tetrahedron
Serial Year
2006
Journal title
Tetrahedron
Record number
1089498
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