Title of article
Synthetic sulfated glucuronosyl paragloboside (SGPG) and its use for the detection of autoimmune peripheral neuropathies
Author/Authors
Reynald Chevalier، نويسنده , , Benoît Colsch، نويسنده , , Carlos Afonso، نويسنده , , Nicole Baumann، نويسنده , , Jean-Claude Tabet، نويسنده , , Jean-Maurice Mallet، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2006
Pages
15
From page
563
To page
577
Abstract
The sulfated glucuronosyl paragloboside SO4-3-GlcA(β1-3)Gal-(β1-4)GlcNAc(β1-3)Gal-(β1-4)Glcβ(1-1′)Cer (SGPG) is a specific constituent of the peripheral nervous system involved in human dysimmune neuropathies. Although it is highly immunogenic in human pathology, it is not a major constituent of peripheral nerve in humans. Pure SGPG is very difficult to obtain from natural sources, but is needed for the design of efficient and reproducible immunoassays. We describe a new chemical synthesis of this important glycolipid with a stearic tail, including its complete characterization by mass spectrometry and its use in the detection of autoimmune neuropathies.
Keywords
SGPG , Sphingoglycolipid , Chemical synthesis , Peripheral nervous system , Neuropathy , Electrospray mass spectrometry
Journal title
Tetrahedron
Serial Year
2006
Journal title
Tetrahedron
Record number
1089520
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