• Title of article

    Synthetic study of tautomycin. Part 2: Synthesis of Ichiharaʹs fragment based on regioselective enzymatic acetylation of complex molecule

  • Author/Authors

    Yusuke Ishii، نويسنده , , Shinji Nagumo، نويسنده , , Takayuki Arai، نويسنده , , Masami Akuzawa، نويسنده , , Norio Kawahara، نويسنده , , Hiroyuki Akita، نويسنده ,

  • Issue Information
    هفته نامه با شماره پیاپی سال 2006
  • Pages
    10
  • From page
    716
  • To page
    725
  • Abstract
    Formal synthesis of tautomycin, which inhibits type 1 and type 2A protein phosphatases, was achieved. Spiroketal diol was synthesized from alcohol or . The regioselective enzymatic acetylation of with the lipase ‘Amano PS’ gave monoacetate in 90% yield, which was converted into Ichiharaʹs intermediate based on Julia coupling and Wittig homologation.
  • Keywords
    tautomycin , Regioselective , Enzymatic acetylation
  • Journal title
    Tetrahedron
  • Serial Year
    2006
  • Journal title
    Tetrahedron
  • Record number

    1089538

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=1089538