A very concise synthesis of a potent N-(1,3-thiazol-2-yl)pyridin-2-amine KDR kinase inhibitor

A very concise synthesis of a potent KDR kinase inhibitor is described. The synthesis features an exceedingly efficient one-pot preparation of the aminothiazole followed by Pd–Xantphos catalyzed cross-coupling with chloropyridine aldehyde . Reductive amination of the resulting aldehyde with the piperazine fragment afforded the final product.