Guanosine and fullerene derived de-aggregation of a new phthalocyanine-linked cytidine derivative

Electronic absorption and emission properties of a new cytidine tethered zinc phthalocyanine were used to probe the aggregation and guanosine/C60 derived de-aggregation of this nucleobase linked phthalocyanine. These experiments revealed that aggregates even at low concentrations in a competitive solvent system (1.1×10−6 M in 20% DCM/toluene). Nucleobase–metal coordination and slipped co-facial π-stacking interactions are both important in aggregate formation. Guanosine , C60 , and a guanosine-C60 chimera were employed as potential aggregate disruptors. These experiments revealed that both guanosine and fullerene subunits are effective in disrupting the aggregate formed by . Such findings support the conclusion that base-pairing, π-stacking, as well as nucleobase–metal coordination interactions play important roles in the de-aggregation of .