Title of article
Synthesis of latonduine derivatives via intramolecular Heck reaction
Author/Authors
Aurélien Putey، نويسنده , , Lionel Joucla، نويسنده , , Laurent Picot، نويسنده , , Thierry Besson، نويسنده , , Benoît Joseph، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
13
From page
867
To page
879
Abstract
The synthesis of indole ring-fused benzazepinone series as latonduine derivatives has been developed via an intramolecular Heck reaction. The scope has been enlarged not only to indole moiety but also to pyrrolo and benzo[b]thiophene nuclei. Several derivatives prepared have been evaluated in vitro for their antiproliferative activities on breast cancer cell lines. Some of them showed promising cytotoxic activities.
Keywords
Indole , Heck , Intramolecular cyclization , Cytotoxic agent
Journal title
Tetrahedron
Serial Year
2007
Journal title
Tetrahedron
Record number
1090116
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