Title of article
Convenient synthesis of antisepsis agent TAK-242 by novel optical resolution through diastereomeric N-acylated sulfonamide derivative
Author/Authors
Atsuko Nishiguchi، نويسنده , , Tomomi Ikemoto، نويسنده , , Kiminori Tomimatsu، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
4
From page
4048
To page
4051
Abstract
A convenient synthesis method of antisepsis agent TAK-242 ((R)-1) through diastereomeric resolution was developed. By condensation of racemate rac-1 with chiral acid (S)-O-acetylmanderic acid (6a), the desired diastereomer 5a was isolated with 98% de in 39% yield by simple crystallization. Deacylation of 5a with aq NaOH followed by recrystallization provided (R)-1 with 99% ee in 20% yield from rac-1.
Keywords
Diastereomeric resolution , Antisepsis agent , Chiral acid , Deacylation , Sulfonamide
Journal title
Tetrahedron
Serial Year
2007
Journal title
Tetrahedron
Record number
1090702
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