Title of article
Dipeptide-catalyzed direct asymmetric aldol reactions in the presence of water
Author/Authors
Meng Lei، نويسنده , , Lanxiang Shi، نويسنده , , Gong Li، نويسنده , , Shilv Chen، نويسنده , , Weihai Fang، نويسنده , , Zemei Ge، نويسنده , , Tieming Cheng، نويسنده , , Runtao Li، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
7
From page
7892
To page
7898
Abstract
The l-proline-based dipeptide has been discovered and developed as an efficient catalyst for the direct asymmetric aldol reactions of unmodified ketones with various aldehydes including aromatic, aliphatic, heteroaromatic, and unsaturated aldehydes in the presence of water at 0 °C. The resulted methodology and optimal conditions led to the corresponding aldol products with high yields (up to 94%) and good enantioselectivities (up to 97% ee).
Keywords
Organocatalysis , asymmetric aldol reaction , In the presence of water , Dipeptide
Journal title
Tetrahedron
Serial Year
2007
Journal title
Tetrahedron
Record number
1091409
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