Title of article
Facile evolution of asymmetric organocatalysts in water assisted by surfactant Brønsted acids
Author/Authors
Sanzhong Luo، نويسنده , , Hui Xu، نويسنده , , Jiuyuan Li، نويسنده , , Long Zhang، نويسنده , , Xueling Mi، نويسنده , , Xiaoxi Zheng، نويسنده , , Jin-Pei Cheng، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
8
From page
11307
To page
11314
Abstract
Simple mixing of chiral amines and surfactant Brønsted acids such as p-dodecyl benzenesulfonic acid (DBSA) leads to highly effective and selective organocatalysts in water. The in situ generated catalysts catalyze highly stereoselective desymmetrization of prochiral ketones via direct aldol reactions (up to >16:1 dr, >99% ee) in water using micelle as reaction media. The current strategy was also applied in asymmetric Michael addition leading to a catalytic system with good activity and stereoselectivity.
Keywords
Chiral amine , Surfactant Br?nsted acids , Aldol , Michael addition
Journal title
Tetrahedron
Serial Year
2007
Journal title
Tetrahedron
Record number
1093408
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