Title of article
Design of 1,2-dioxines with anti-Candida activity: aromatic substituted 1,2-dioxines
Author/Authors
Ian G. Macreadie، نويسنده , , Thomas D. Avery، نويسنده , , Tony V. Robinson، نويسنده , , Peter Macreadie، نويسنده , , Miles Barraclough، نويسنده , , Dennis K. Taylor، نويسنده , , Edward R.T. Tiekink، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
8
From page
1225
To page
1232
Abstract
In an ongoing effort to rationally design new antimicrobials, 47 new 1,2-dioxines have been synthesised. Broad antifungal structure–activity relationships governing aromatically substituted epoxy-1,2-dioxines 2 and 3 and their parent 1,2-dioxines 1 were assessed primarily against the pathogenic yeast, Candida albicans, with haemolytic activity of selected examples also reported.
Keywords
2-Dioxine , Candida , Epoxy-1 , Haemolytic activity , Antifungal , 2-Dioxine , 1
Journal title
Tetrahedron
Serial Year
2008
Journal title
Tetrahedron
Record number
1093711
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