Title of article
Chlorahololides C–F: a new class of potent and selective potassium channel blockers from Chloranthus holostegius
Author/Authors
Sheng-Ping Yang، نويسنده , , Zhao-Bing Gao، نويسنده , , Yan Wu، نويسنده , , Guo-Yuan Hu، نويسنده , , Jian-Min Yue، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
8
From page
2027
To page
2034
Abstract
Four unusually fused polycyclic sesquiterpenoid dimers, chlorahololides C–F (1–4), were isolated from the whole plant of Chloranthus holostegius. Their structures and absolute configurations were established by spectroscopic methods, including 2D NMR and CD spectra. Chlorahololides C–F (1–4) exerted potent and selective inhibition on the delayed rectifier (IK) K+ current with the IC50 values of 3.6±10.1, 2.7±0.3, 27.5±5.1 and 57.5±6.1 μM, respectively.
Keywords
Potassium channel blocker , Chlorahololides C–F , Chloranthus holostegius , Structural elucidation
Journal title
Tetrahedron
Serial Year
2008
Journal title
Tetrahedron
Record number
1093799
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