A cycloalkane-based thermomorphic system for palladium-catalyzed cross-coupling reactions

In this paper, we describe a practical and efficient protocol for Sonogashira, Suzuki–Miyaura, and Mizoroki–Heck cross-coupling using a CBT system. The use of substrates with cycloalkane-soluble tags facilitates separation of the desired products and the homogeneous Pd catalyst via simple liquid–liquid extraction, thereby eliminating the need for a catalyst removal process.