Title of article
Enantioselective route to 3-vinylidene tetrahydropyrans and 3-vinylidene oxepanes based on a silyl-Prins cyclization
Author/Authors
Bart?omiej Furman، نويسنده , , Magdalena Dziedzic، نويسنده , , Iwona Justyniak، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
8
From page
3103
To page
3110
Abstract
A general method has been developed for the asymmetric synthesis of 3-vinylidene tetrahydropyrans and 3-vinylidene oxepanes based on the Lewis acid-catalyzed intramolecular reactions of oxocarbenium ions with propargylsilanes. The observed excellent diastereoselectivity and a high asymmetric induction offer a new synthetic method with a wide scope and generality.
Keywords
propargylsilanes , oxepanes , Asymmetric synthesis , Prins cyclization , Tetrahydropyrans
Journal title
Tetrahedron
Serial Year
2008
Journal title
Tetrahedron
Record number
1093907
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