Title of article
Determination of the absolute structure of albaconol
Author/Authors
Mikio Fujii، نويسنده , , Sadayuki Ishii، نويسنده , , Ryota Saito، نويسنده , , Hiroyuki Akita، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
3
From page
5147
To page
5149
Abstract
The concise synthesis of (8aR)-(−)-albaconol (1) from (8aR)-albicanol (2) obtained from the lipase-assisted asymmetric acetylation of rac-2, was achieved in 45% overall yield (eight steps). By comparison of the sign of specific rotation of between synthetic (8aR)-(−)-albaconol (1) and natural (+)-albaconol (1), the absolute structure of natural (+)-1 was determined to be 1R,2R,4aS,8aS configuration.
Keywords
(8aR)-Albaconol , natural product synthesis , Structure elucidation
Journal title
Tetrahedron
Serial Year
2008
Journal title
Tetrahedron
Record number
1094120
Link To Document