Title of article
Synthesis and spectroscopic characterization of binaphthol aminosugars for stimulation of DNA strand slippage synthesis
Author/Authors
Liangliang Liu، نويسنده , , Long Yi، نويسنده , , Xing Yang، نويسنده , , Zhihong Yu، نويسنده , , Xin Wen، نويسنده , , Zhen-Xi Zhuo، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
6
From page
5885
To page
5890
Abstract
Expansion of DNA repeat sequences is associated with many human genetic diseases. Bulged DNA structures have been implicated as intermediates in DNA slippage within the DNA repeat regions. Two new binaphthol aminosugars were first synthesized as DNA bulge binders to study the triplet repeat expansion due to the wedge-shaped structure of 1,1′-bi-2-naphthol. Both compounds were structurally characterized by 1- and 2-D NMR. They showed remarkable fluorescence enhancement when binding with bulge DNA and they exhibited stimulation for ATT·AAT trinucleotide repeat DNA sequence slippage synthesis.
Keywords
Wedge-shaped structure , Trinucleotide repeat , Slippage synthesis , Binaphthol , DNA
Journal title
Tetrahedron
Serial Year
2008
Journal title
Tetrahedron
Record number
1094216
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