Title of article
Total synthesis and analgesic activity of 6-fluoroindan-1-carboxylic acid
Author/Authors
Sharmistha Das، نويسنده , , Hasina Yasmin، نويسنده , , M. Mehedi Masud، نويسنده , , Suvas C. Roy، نويسنده , , Lutfun Nahar، نويسنده , , M. Mukhlesur Rahman، نويسنده , , Simon Gibbons، نويسنده , , Sitesh C. Bachar، نويسنده , , Satyajit D. Sarker، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
4
From page
8642
To page
8645
Abstract
6-Fluoroindan-1-carboxylic acid (4) was conveniently synthesised from 3-fluorobenzaldehyde in six steps. The structure of this new compound and three other intermediates, 3-fluorophenylcyanoethylacrylate (1), 3-fluorophenyl succinic acid (2) and 6-fluoro-3-oxo-indan-1-carboxylic acid (3) was elucidated by comprehensive spectral data analyses. The analgesic activity of compounds 3 and 4 was assessed by the acetic acid induced writhing in Swiss albino mice.
Keywords
3-Fluorophenyl succinic acid , 6-Fluoroindan-1-carboxylic acid , 6-Fluoro-3-oxo-indan-1-carboxylic acid , 3-Fluorophenylcyanoethylacrylate , Analgesic activity
Journal title
Tetrahedron
Serial Year
2008
Journal title
Tetrahedron
Record number
1094536
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