Title of article
A theoretical study on the decomposition mechanism of artemisinin
Author/Authors
Pamela Moles، نويسنده , , M?nica Oliva، نويسنده , , Vicent S. Safont، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
16
From page
9448
To page
9463
Abstract
A theoretical study on the artemisinin decomposition mechanism is reported. The suggested pathways have been reproduced and the appearance of the final products can be explained in a satisfactory way. In addition, several intermediates and radicals have been found as relatively stable species, thus giving support to the current hypothesis that some of these species can be responsible for the antimalarial action of artemisinin and its derivatives.
Keywords
malaria , Trioxane chemistry , DFT calculations , C-Radical intermediates
Journal title
Tetrahedron
Serial Year
2008
Journal title
Tetrahedron
Record number
1094630
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