Electrocatalytic cascade multicomponent assembling: stereoselective one-pot synthesis of the substituted 3-azabicyclo[3.1.0]hexane-1-carboxylate system from aldehyde, malononitrile, malonate and methanol

Electrolysis of aromatic aldehydes, malononitrile and malonate in methanol in an undivided cell in the presence of sodium bromide–sodium methoxide as double mediatory system results in the stereoselective formation of methyl (1R∗,5R∗,6R∗) 6-substituted 5-cyano-4,4-dialkoxy-2-oxo-3-azabicyclo[3.1.0]hexane-1-carboxylates in 50–70% yields.