Title of article
Synthesis of tetracyclic dioxygenated isoquinolines and their cytotoxic activity
Author/Authors
Manel Romero، نويسنده , , Daniel-Henry Caignard، نويسنده , , Pierre Renard، نويسنده , , M. Dolors Pujol، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
8
From page
11020
To page
11027
Abstract
An efficient synthesis of new dioxygenated isoquinolines is reported. The novelty of this approach derives from its use of tricyclic-nitril (3) as a building block in a synthetic sequence of seven steps for the preparation of the tetracyclic isoquinoline (14) and its derivatives. The isoquinoline 16 was 10-fold more active against leukemia L1210 than the corresponding tetrahydroisoquinoline 14.
Keywords
polycyclic compounds , Dioxygenated isoquinoline , Phenethylamine derivatives , antitumor compounds
Journal title
Tetrahedron
Serial Year
2008
Journal title
Tetrahedron
Record number
1094817
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