Title of article
Highly diastereoselective Barbier allylation and iminium cyclization: a simple entry to bicyclic and tricyclic piperazinones
Author/Authors
A. Viso، نويسنده , , R. Fern?ndez de la Pradilla، نويسنده , , A. Flores، نويسنده , , M.A. del ?guila، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
9
From page
11580
To page
11588
Abstract
Barbier allylation of 5,6-dihydropyrazin-2(1H)-ones leads to a single isomer of 3-allylpiperazin-2-ones in high yields. Further Pictet–Spengler–Grieco cyclization of 3-allylpiperazin-2-ones with aldehydes provides bicyclic and tricyclic piperazinones with high diastereoselectivity.
Keywords
piperazines , Diastereoselective allylation , Iminium cyclization
Journal title
Tetrahedron
Serial Year
2008
Journal title
Tetrahedron
Record number
1094886
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