Title of article
Efficient microwave-assisted synthesis of 4-amino-2-benzazepin-3-ones as conformationally restricted dipeptide mimetics
Author/Authors
Beatrice Severino، نويسنده , , Ferdinando Fiorino، نويسنده , , Antonella Esposito، نويسنده , , Francesco Frecentese، نويسنده , , Francesca De Angelis، نويسنده , , Elisa Perissutti، نويسنده , , Giuseppe Caliendo، نويسنده , , Vincenzo Santagada، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
6
From page
206
To page
211
Abstract
In this paper, we describe the synthesis of conformationally constrained dipeptide mimetic derivatives. Microwave flash heating was used in several synthetic steps providing the opportunity to perform the reactions in dramatically shortened time as well as to increase the obtained yields. The efficiency of the methodology makes it useful in order to prepare other dipeptides containing the 4-amino-tetrahydro-2-benzazepin-3-one motif.
Keywords
constrained amino acids , peptide mimetic , Microwave irradiation , Intramolecular , Friedel–Crafts cyclization
Journal title
Tetrahedron
Serial Year
2009
Journal title
Tetrahedron
Record number
1094956
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