Cinnacassides A–E, five geranylphenylacetate glycosides from Cinnamomum cassia

Cinnacassides A–E (1–5), five novel glycosides with a unique geranylphenylacetate carbon skeleton, were isolated from the stem bark of Cinnamomum cassia. Each of the cinnacassides A–D (1–4) possesses one of the four stereoisomers in the aglycone. Their structures were established by extensive spectroscopic analysis and chemical and chiroptical methods. A plausible biosynthetic route to 1–5 was also proposed.