Title of article
Formal synthesis of salinosporamide A via NHC-catalyzed intramolecular lactonization
Author/Authors
Justin R. Struble، نويسنده , , Jeffrey W. Bode، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
11
From page
4957
To page
4967
Abstract
An N-heterocyclic carbene (NHC) catalyzed intramolecular lactonization to prepare densely functionalized bicyclic γ-lactam-γ-lactone adducts from enals is reported. This method has been applied to the formal synthesis of salinosporamide A, a potent 20S proteasome inhibitor and anti-cancer therapeutic.
Keywords
?-Chiral amines , Asymmetric catalysis , Chemoselectivity , Heterocycles , Functionalized imines
Journal title
Tetrahedron
Serial Year
2009
Journal title
Tetrahedron
Record number
1095531
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