Title of article
Synthesis and in vitro activity of 6-amino-2,9-diarylpurines for Mycobacterium tuberculosis
Author/Authors
Carla Correia، نويسنده , , M. Alice Carvalho، نويسنده , , M. Fernanda Proença، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
9
From page
6903
To page
6911
Abstract
A mild method was developed to synthesize 6-amino-2-phenolic-9-alkyl and 9-arylpurines. The new compounds were screened for antibacterial activity against Mycobacterium tuberculosis strain H37Rv. The 9-tolyl derivatives with a dimethylamino or a piperidine substituent in C6 and the 3-hydroxyphenyl or 4-hydroxyphenyl substituent in C2 were highly active against the bacilli.
Keywords
Density functional theory (DFT) , Nucleophilic vinylic substitution , Sulfur-containing heterocycles , SNV? and SNV? mechanisms
Journal title
Tetrahedron
Serial Year
2009
Journal title
Tetrahedron
Record number
1097599
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