Title of article
Chemoselective hydrogenation of 17α-hydroxy-6-methylen-pregna-4,9(11)-diene-3,20-dione. Synthesis of fluorometholone
Author/Authors
Andrés Marcos Escribano، نويسنده , , Francisco A. Bermejo، نويسنده , , Antonio Lorente Bonde-Larsen، نويسنده , , Jes?s Iglesias Retuerto، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
4
From page
8493
To page
8496
Abstract
The development of an efficient hydrogenation method of 17α-hydroxy-6-methylen-pregna-4,9(11)-diene-3,20-dione by using wet (10%) Pd on carbon and triethylamine led us to the corresponding 6α-methyl-pregnane in good yield. This chemoselective process allowed us to set up a large-scale procedure for the synthesis of the ophthalmic drug fluorometholone with 45% overall yield.
Keywords
chemoselective hydrogenation , Fluorometholone , Chloranil , Steroids
Journal title
Tetrahedron
Serial Year
2009
Journal title
Tetrahedron
Record number
1097813
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