Title of article
The preparation of optically active α-amino 4H-[1,2,4]oxadiazol-5-ones from optically active α-amino acids
Author/Authors
John E. Mangette، نويسنده , , Matthew R. Johnson، نويسنده , , Van-Duc Le، نويسنده , , Rajesh A. Shenoy، نويسنده , , W. Howard Roark، نويسنده , , Michael Stier، نويسنده , , Thomas Belliotti، نويسنده , , Thomas Capiris، نويسنده , , Peter R. Guzzo، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2009
Pages
6
From page
9536
To page
9541
Abstract
Optically active α-amino 4H-[1,2,4]oxadiazol-5-ones (oxadiazolones) were prepared from optically active α-amino acids in five synthetic steps. The oxadiazolone moiety serves as a bioisosteric replacement for the carboxylic acid. Incorporation of an α-amino oxadiazolone into a representative dipeptide mimic is described.
Keywords
Optically active , ?-amino acid , Bioisostere , Oxadiazolone
Journal title
Tetrahedron
Serial Year
2009
Journal title
Tetrahedron
Record number
1099234
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