α N–O turn induced by fluorinated α-aminoxy diamide: synthesis and conformational studies

Two α-aminoxy diamides with fluorinated side chains were synthesized. Their secondary structures characterization was carried out by 1H NMR, and IR spectrometries as well as X-ray crystallography studies. α N–O turn secondary structures are adopted insusceptibly by side-chain-fluorinated α-aminoxy residues. Thus the fluorinated α-aminoxy diamide can be a potential residue as a biological tracer to be incorporated into aminoxy peptides.