Title of article
Total synthesis of 3,3-difluorinated 1-deoxynojirimycin analogues
Author/Authors
René Csuk، نويسنده , , Erik Prell، نويسنده , , Claudia Korb، نويسنده , , Ralph Kluge، نويسنده , , Dieter Str?hl، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
6
From page
467
To page
472
Abstract
Difluorination of 1-deoxynojirimycin at position C(3) creates a competitive inhibitor 15 of 10 times higher activity against an α-glucosidase than the parent compound. Its screening against a panel of human cell lines showed a low cytotoxicity therefore making this compound an interesting candidate for further clinical investigations.
Keywords
Difluorination , 1-Deoxynojirimycin , ?-Galactosidase inhibitor , ?-Glucosidase inhibitor
Journal title
Tetrahedron
Serial Year
2010
Journal title
Tetrahedron
Record number
1100448
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