Title of article
Sonogashira reactions of α- and β-1-ethynyl-2-deoxyribosides: synthesis of acetylene-extended C-nucleosides
Author/Authors
Tom?? Bobula، نويسنده , , Michal Hocek، نويسنده , , Martin Kotora، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
7
From page
530
To page
536
Abstract
An improved practical protocol for the synthesis of both anomers of 1-ethynyl-2-deoxiribosides 1 was developed. The Sonogashira coupling of ethynyldeoxyribosides 1 with various aryl- and heteroaryl halides was carried out under various conditions. It was found that the use of copper-free coupling protocols could reduce the oxidative dimerisation in favour of arylalkynyldeoxyriboside formation.
Keywords
alkynes , C-Nucleosides , aryl halides , cross-coupling reactions
Journal title
Tetrahedron
Serial Year
2010
Journal title
Tetrahedron
Record number
1100458
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