Title of article
Structure and absolute configuration of 3-alkylpiperidine alkaloids from an Indonesian sponge of the genus Halichondria
Author/Authors
I. Wayan Mudianta، نويسنده , , Peter L. Katavic، نويسنده , , Lynette K. Lambert، نويسنده , , Patricia Y. Hayes، نويسنده , , Martin G. Banwell، نويسنده , , Murray H.G. Munro، نويسنده , , Paul V. Bernhardt، نويسنده , , Mary J. Garson، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
9
From page
2752
To page
2760
Abstract
Chemical analysis of an Indonesian sponge sample has provided three new 3-alkylpiperidine alkaloids, tetradehydrohaliclonacyclamine A, its mono-N-oxide derivative, and a 2-epi isomer. The absolute structure of tetradehydrohaliclonacyclamine A has been established by X-ray crystallography from anomalous dispersion effects using Cu radiation, which determined that the absolute configuration is 2S, 3S, 7S, 9S while an HPLC study revealed that the alkaloid is enantiomerically pure.
Keywords
Sponge , 3-Alkylpiperidine , N-oxide , X-ray analysis , NMR , Halichondria , Absolute configuration , Biosynthesis
Journal title
Tetrahedron
Serial Year
2010
Journal title
Tetrahedron
Record number
1100723
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