Title of article
Enantioselective synthesis of (S)-4-methyleneglutamic acid via tandem conjugate addition–elimination under phase-transfer catalytic conditions
Author/Authors
Sukhoon Kang، نويسنده , , Qinghua Shi، نويسنده , , Min-Woo Ha، نويسنده , , Jin-Mo Ku، نويسنده , , Maosheng Cheng، نويسنده , , Byeong-Seon Jeong، نويسنده , , Hyeung-geun Park، نويسنده , , Sang-sup Jew، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
4
From page
4326
To page
4329
Abstract
An efficient enantioselective synthetic method for (S)-4-methyleneglutamic acid is reported. Phase-transfer catalytic conjugate addition–elimination of the benzophenone imine of glycine tert-butyl ester in the presence of chiral Cinchona-derived catalysts give the corresponding conjugated addition products (>99% ee), which could be hydrolyzed to chiral (S)-4-methyleneglutamic acid.
Journal title
Tetrahedron
Serial Year
2010
Journal title
Tetrahedron
Record number
1100910
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