Title of article
Enantioselective total synthesis of idesolide via NaHCO3-promoted dimerization
Author/Authors
Tomohiro Nagasawa، نويسنده , , Naoyuki Shimada، نويسنده , , Munefumi Torihata، نويسنده , , Shigefumi Kuwahara، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
5
From page
4965
To page
4969
Abstract
The enantioselective total synthesis of idesolide has been accomplished in 20% overall yield from a known allylic alcohol by a nine-step sequence involving the Sharpless asymmetric epoxidation as the source of chirality and an efficient NaHCO3-promoted dimerization of the monomeric form of idesolide as the key transformation.
Keywords
Spiro compounds , Antiinflammatory , Total synthesis , Idesolide , Dimerization
Journal title
Tetrahedron
Serial Year
2010
Journal title
Tetrahedron
Record number
1100985
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