Title of article
An efficient synthesis of 6,9-disubstituted purin-8-ones via copper-catalyzed coupling/cyclization
Author/Authors
Qi-Fei Zhong، نويسنده , , Li-Ping Sun، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
5
From page
5107
To page
5111
Abstract
An efficient and novel synthesis of 6,9-disubstituted purin-8-ones has been developed. Starting from dichloropyrimidin-5-ylcarbamate, CuCl/amino acid catalyzed coupling/cyclization reaction with amines was achieved to afford 9-substituted 6-chloropurin-8-ones. Then a microwave-assisted amination procedure was carried out for the synthesis of 6,9-disubstituted purin-8-ones in moderate to good yields.
Keywords
Purin-8-ones , Microwave-assisted synthesis , Copper-catalyzed coupling/cyclization
Journal title
Tetrahedron
Serial Year
2010
Journal title
Tetrahedron
Record number
1101004
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