Title of article
Asymmetric metal-free synthesis of fluoroquinolones by organocatalytic hydrogenation
Author/Authors
Magnus Rueping، نويسنده , , Mirjam Stoeckel، نويسنده , , Erli Sugiono، نويسنده , , Thomas Theissmann، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
4
From page
6565
To page
6568
Abstract
A highly enantioselective organocatalytic transfer hydrogenation enabling the synthesis of both 6-fluoro-2-methyltetrahydroquinoline and 7,8-difluoro-3-methyl-benzoxazine has been developed. These key building blocks can for the first time be synthesized using the same methodology allowing fast and efficient, metal-free access to the antibiotic fluoroquinolones flumequine and levofloxacine.
Keywords
asymmetric reduction , Levofloxacine , Br?nsted acid , Flumequine , Organocatalysis
Journal title
Tetrahedron
Serial Year
2010
Journal title
Tetrahedron
Record number
1101175
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