Design and automated generation of artificial estrogen receptor as potential endocrine disruptor chemical binders

We here report on our results concerning the systematic design and synthesis of a new type of artificial estrogen receptor candidates. Our interest herein originates from the known estrogenic activity of endocrine disrupting chemicals, environmental pollutants that have attracted increased attention due to their interference with the endocrine and reproductive system of wildlife and humans. An automated protocol for the generation of libraries of potential artificial receptors is described. The resulting structures could find application in novel SPE cartridges for EDC-preconcentration.