Title of article
Formal total synthesis of ottelione using iridium-catalyzed oxidative desymmetrization
Author/Authors
Takeyuki Suzuki، نويسنده , , Kazem Ghozati، نويسنده , , Da-Yang Zhou، نويسنده , , Tadashi Katoh، نويسنده , , Hiroaki Sasai، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
7
From page
7562
To page
7568
Abstract
A catalytic asymmetric synthesis of a key intermediate for ottelione has been achieved using oxidative desymmetrization as the critical step. This oxidative desymmetrization was efficiently promoted by an iridium diamine complex to give the desired hydroxy ketone in >99% ee and 60% yield.
Keywords
Iridium , Oxidative desymmetrization , Ottelione , Hydrogen-transfer reaction , meso diol
Journal title
Tetrahedron
Serial Year
2010
Journal title
Tetrahedron
Record number
1101294
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