Title of article
Enantioselective alkynylation of carbonyl compounds with trimethoxysilylalkynes catalyzed by lithium binaphtholate
Author/Authors
Tomohiro Ueda، نويسنده , , Kana Tanaka، نويسنده , , Tomonori Ichibakase، نويسنده , , Yuya Orito، نويسنده , , Makoto Nakajima، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
6
From page
7726
To page
7731
Abstract
Enantioselective alkynylation of aldehydes and ketones was accomplished using trimethoxysilylalkynes as alkynylating reagents and lithium 3,3′-diphenylbinaphtholate as a catalyst. Optically active propargylic alcohols were obtained in good to high chemical yields and enantioselectivities. Alkynylation of acetylpyridines afforded biologically active pyridyl propargylic alcohols in good enantioselectivities.
Keywords
enantioselective catalysis , Lithium binaphtholate , Alkynylation , Trimethoxysilylalkyne
Journal title
Tetrahedron
Serial Year
2010
Journal title
Tetrahedron
Record number
1101310
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